Revista Fitos
Úlceras gástricas são lesões no revestimento da mucosa gástrica que trazem como sintomas dor epigástrica e queimação, que são amenizados empiricamente por derivados extrativos de Eugenia brasiliensis Lam. (Myrtaceae). Contudo, não há estudos que avaliaram sistematicamente o seu potencial gastroprotetor. Assim, o objetivo do presente trabalho foi avaliar a eficácia de um extrato de Eugenia brasiliensis em reduzir lesões gástricas em ratas. Grupos de animais foram submetidos à lesão gástrica por etanol e indometacina após tratamento prévio com o extrato e à lesão por ácido acético seguida de seis dias de tratamento com o extrato. Houve redução da área de lesão induzida por etanol nas doses de 30 e 100 mg/Kg de extrato de 36 e 68%, respectivamente. Tratamento prévio com as doses de 30, 100 e 300 mg/Kg do extrato promoveu, respectivamente, inibição de 66%, 88% e 73% da área de lesão por indometacina e o extrato foi capaz de reduzir em 72% a área de lesão por ácido acético na dose de 100 mg/Kg. O extrato foi eficaz em reduzir a área de lesão nos três modelos, possivelmente devido à presença de polifenois anti-inflamatórios e antioxidantes, que podem reduzir o dano celular e a área de lesão gástrica.
DOI
10.32712/2446-4775.2023.1555
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