Revista Fitos
Cenostigma pyramidale (“catingueira” ou ‘‘pau-de-rato’’) é amplamente utilizada na medicina popular brasileira para tratar diversas doenças, incluindo diarreia. Este estudo teve como objetivo avaliar as atividades espasmolítica e antidiarreica in vitro dos extratos das folhas e cascas do caule de Cenostigma pyramidale e correlacioná-las com a medicina tradicional. No íleo isolado de cobaia, a fração triclorometano do extrato da casca do caule apresentou atividade espasmolítica concentração-dependente em preparações pré-contraídas com KCl 40 mM [logCE50 = 1,690 ± 0,09625 µg/mL]. Em camundongos, o extrato da casca do caule em doses de 250 ou 500 mg/kg reduziu a massa total das fezes; extratos de folhas e cascas de caule reduziram o trânsito intestinal em 250, 500 ou 750 mg/kg; e 750 mg/kg de extrato de folhas reduziram o acúmulo de líquido intestinal. Concluindo, o efeito antidiarreico de Cenostigma pyramidale pode estar relacionado à inibição da contração da musculatura lisa, provavelmente devido à presença de taninos e flavonoides nos extratos.
DOI
10.32712/2446-4775.2026.1845
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Sousa LMS, Santos BNG, Medeiros MDGF, Lima IBC, Santos-Filho FS, Santana ACSGV, et al. Poincianella pyramidalis (Tul) L.P. Queiroz: A review on traditional uses, phytochemistry and biological-pharmacological activities. J Ethnopharmacol. 2021; 264: 113181. ISSN: 0378-8741. [acesso em: 11 jul. 2024]. Available: [https://doi.org/10.1016/j.jep.2020.113181].
Souza CS, Grangeiro MS, Pereira EPL, Santos CC, Silva AB, Sampaio GP, et al. Agathisflavone, a flavonoid derived from Poincianella pyramidalis (Tul.), enhances neuronal population and protects against glutamate excitotoxicity. Neurotoxicology. 2018; 65: 85-97. [acesso em: 11 jul. 2024]. Available: [https://doi.org/10.1016/j.neuro.2018.02.001].
Gagnon E, Bruneau A, Hughes CE, De Queiroz LP, Lewis GP. A new generic system for the pantropical Caesalpinia group (Leguminosae). PhytoKeys. 2016; 71: 1-160. [acesso em: 11 jul. 2024]. Available:https://doi.org/10.3897/phytokeys.71.9203].
Harborne AJ. Phytochemical methods are a guide to modern techniques of plant analysis. 3th ed. Springer science & Business media. 1998. ISBN-0412572605.
Giliani AU, Ghayur MN, Khalid A, Zaheer-ul-Haq, Choudhary MI, Atta-ur-Rahman. Presence of antispasmodic, antidiarrheal, antisecretory, calcium antagonist and acetylcholinesterase inhibitory steroidal alkaloids in Sarcococca saligna. Pl Med. 2005; 71:120-125. [acesso em: 20 ago. 2024]. Available: [https://doi.org/10.1055/s-2005-837777].
Rao VS, Santos FA, Sobreira TT, Souza MF, Melo CL, Silveira ER. Investigations on the gastroprotective and antidiarrhoeal properties of ternatin, a tetramethoxyflavone from Egletes viscosa. Pl Med. 1997; 63:146-149. [acesso em: 20 ago. 2024]. Available: [https://doi.org/10.1055/s-2006-957632].
Borrelli F, Capasso F, Capasso R, Ascione V, Aviello G, Longo R, Izzo AA. Effect of Boswellia serrata on intestinal motility in rodents: inhibition of diarrhoea without constipation. 2006. Br J Pharmacol. 148:553-560. [acesso em: 20 ago. 2024]. Available: [https://doi.org/10.1038/sj.bjp.0706740].
Di Carlo G, Autore G, Izzo AA, Maiolino P, Mascolo N, Viola P, et al. Inhibition of intestinal motility and secretion by flavonoids in mice and rats: structure-activity relationships. J Pharm Pharmacol. 1993; 45: 1054-1059. [acesso em: 20 ago. 2024]. Available: [https://doi.org/10.1111/j.2042-7158.1993.tb07180.x].
Bahia MV, Santos JB dos, David JP, David JM. Biflavonoids and other phenolics from Caesalpinia pyramidalis (Fabaceae). J Braz Chem Soc. 2005; 16(6b): 1402–5. [acesso em: 11 jul. 2024]. Available: [https://doi.org/10.1590/S0103-50532005000800017].
Melo JG, Araújo TAS, Castro VTNA, Cabral DLV, Rodrigues MD, et al. Antiproliferative activity, antioxidant capacity and tannin content in plants of semi-arid northeastern Brazil. Molecules. 2010; 15(12): 8534-42. [acesso em: 11 jul. 2024]. Available: [https://doi.org/10.3390/molecules15128534].
Moraes SZDC, Shan AYKV, Melo MAO, Silva JP, Passos FRS, Souza AG, et al. Antinociceptive and anti-inflammatory effect of Poincianella pyramidalis (Tul.) LP Queiroz. J Ethnopharmacol. 2020; 254: 112563. [acesso em: 11 jul. 2024]. Available: [https://doi.org/10.1016/j.jep.2020.112563].
Billah MM, Islam R, Khatun H, Parvin S, Islam E, Islam SA, et al. Antibacterial, antidiarrhoeal, and cytotoxic activities of methanol extract and its fractions of Caesalpinia bonducella (L.) Roxb leaves. BMC Complement Altern Med. 2013; 13:101. [acesso em: 11 jul. 2024]. Available: [https://doi.org/10.1186/1472-6882-13-101].
Ribeiro AR, Diniz PB, Estevam CS, Pinheiro MS, Albuquerque-Júnior RL, Thomazzi SM. Gastroprotective activity of the ethanol extract from the inner bark of Caesalpinia pyramidalis in rats. J Ethnopharmacol. 2013; 147(2): 383-8. [acesso em: 11 jul. 2024]. Available: [https://doi.org/10.1016/j.jep.2013.03.023].
Diniz PB, Ribeiro AR, Estevam CS, Bani CC, Thomazzi SM. Possible mechanisms of action of Caesalpinia pyramidalis in ethanol-induced gastric damage. J Ethnopharmacol. 2015; 168: 79-86. [acesso em: 11 jul. 2024]. Available: [https://doi.org/10.1016/j.jep.2015.03.054].
Souza SD, Franca CS, Niculau ES, Costa LC, Pinto JE, Alves PB, et al. Antispasmodic effect of Ocimum selloi essential oil on the guinea-pig ileum. Nat Prod Res. 2015; 29(22): 2125-8. [acesso em: 21 nov. 2024]. Available: [https://doi.org/10.1080/14786419.2014.989392].
Galheigo MR, Prado LC, Mundin AM, Gomes DO, Chang R, Lima AM, et al. Antidiarrhoeic effect of Eugenia dysenterica DC (Myrtaceae) leaf essential oil. Nat Prod Res. 2016; 30(10): 1182-5. [acesso em: 21 nov. 2024]. Available: [https://doi.org/10.1080/14786419.2015.1043633].
Tunaru S, Althoff TF, Nüsing RM, Diener M, Offermanns S. Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors. Proc Natl Acad Sci U S A. 2012; 109(23): 9179-9184. [acesso em: 21 nov. 2024]. Available: [https://doi.org/10.1073/pnas.1201627109].
Kumral D, Zfass AM. Gut Movements: A Review of the Physiology of Gastrointestinal Transit. Dig Dis Sci. 2018; 63(10): 2500-2506. [acesso em: 21 nov. 2024]. Available: [https://doi.org/10.1007/s10620-018-5259-1].
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